PUBLICATIONS

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2018,

Long, J.Z., Roche, A.M., Berdan, C.A., Louie, S.M., Roberts, A.J., Svensson, K.J., Dou, F.Y., Bateman, L.A., Mina, A.I., Deng, Z., Jedrychowski, M.P., Lin, H., Kamenecka, T.M., Asara, J.M., Griffin, P.R., Banks, A.S., Nomura, D.K., Spiegelman, B.M. Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception. Proc Natl Acad Sci U S A. 2018 Jul 2. PMID: 29967167.

Lin, H., Long, J.Z., Roche, A.M., Svensson, K.J., Dou, F.Y., Chang, M.R., Strutzenberg, T., Ruiz, C., Cameron, M.D., Novick, S.J., Berdan, C.M., Louie, S., Nomura, D.K., Spiegelman, B.M., Griffin, P.R., Kamenecka, T.M. Discovery of Hydrolysis-resistant Isoindoline N-Acyl Amino Acid Analogs that Stimulate Mitochondrial Respiration. J Med Chem. 2018,12;61(7):3224-3230 PMID: 29533650.


2016

Long, J.Z., Svensson, K.J., Bateman, L.A., Lin, H., Kamenecka, T., Lokurkar, I.A., Lou, J., Rao, R.R., Chang, M.R., Jedrychowski, M., Paulo, J.A., Gygi, S.P., Griffin, P.R., Nomura, D.K., Spiegelman, B.M. PM20D1 secretion by thermogenic adipocytes regulates lipidated amino acid uncouplers of mitochondrial respiration. Cell. 2016 166(2):424-35. PMCID: PMC4947008.

Menard, J.A., Christianson, H.C., Kucharzewska, P., Bourseau-Guilmain, E., Svensson, K.J., Lindqvist, E., Chandran, V.I., Kjellén, L., Bengzon, J., Johansson, M.C., Belting, M. Hypoxia and acidosis induced extracellular lipid uptake promotes metastasis through proteoglycan dependent endocytosis. Cancer Res. 2016 May 19. pii: canres.2831.2015. PubMed PMID: 27199348.

Svensson, K.J., Long, J.Z., Jedrychowski, M.P., Cohen, P., Lo, J.C., Serag, S., Kir, S., Shinoda, K., Tartaglia, J.A., Rao, R.R., Chédotal, A., Kajimura, S., Gygi, S.P., Spiegelman, B.M. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 23(3):454-66 PubMed PMCID: PMC4785066.  PDF


2014

Christianson, H.C., Svensson, K.J., Belting, M. Exosome and microvesicle mediated phene transfer in mammalian cells. Semin Cancer Biol. 2014 Oct;28:31-8. PMID: 24769057.

Rao, R.R., Long, J.Z., White, J.P., Svensson, K.J., Lou, J., Lokurkar, I., Jedrychowski, M.P., Ruas, J.L., Wrann, C.D., Lo, J.C., Camera, D.M., Lachey, J., Gygi, S., Seehra, J., Hawley, J.A., Spiegelman, B.M. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 2014 Jun 5;157(6):1279-91. PMCID: PMC4131287.

Long, J.Z., Svensson, K.J., Tsai, L., Zeng, X., Roh, H.C., Kong, X., Rao, R.R., Lou, J., Lokurkar, I., Baur, W., Castellot, J.J. Jr, Rosen, E.D., Spiegelman, B.M. A smooth muscle-like origin for beige adipocytes. Cell Metab. 2014 May 6;19(5):810-20. PMCID: PMC4052772.

Cohen, P., Levy, J.D., Zhang, Y., Frontini, A., Kolodin, D.P., Svensson, K.J., Lo, J.C., Zeng, X., Ye, L., Khandekar, M.J., Wu, J., Gunawardana, S.C., Banks, A.S., Camporez, J.P., Jurczak, M.J., Kajimura, S., Piston, D.W., Mathis, D., Cinti, S., Shulman, G.I., Seale, P., Spiegelman, B.M. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16;156(1-2):304-16. PMCID: PMC3922400.


2013

Christianson, H.C., Svensson, K.J., van Kuppevelt, T.H., Li, J.P., Belting, M. Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17380-5. PMCID: PMC3808637.

Svensson, K.J.*, Christianson, H.C., Wittrup, A., Bourseau-Guilmain, E., Lindqvist, E., Svensson, L.M., Mörgelin, M., Belting, M. Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem. 2013 Jun 14;288(24):17713-24. Epub 2013 May 7. PMCID: PMC3682571.  * Corresponding author.

Kucharzewska, P., Christianson, H.C., Welch, J.E., Svensson, K.J., Fredlund, E., Ringnér, M., Morgelin, M., Bourseau-Guilmain, E., Bengzon, J., Belting, M. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7312-7. PMCID: PMC3645587.

Svensson, K.J., Belting, M. Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment. Biochem Soc Trans. 2013 Feb 1;41(1):273-6. PubMed PMID: 23356296.


2012

Marko-Varga, G., Végvári, Á., Welinder, C., Lindberg, H., Rezeli, M., Edula, G., Svensson, K.J., Belting, M., Laurell, T., Fehniger, T.E. Standardization and utilization of biobank resources in clinical protein science with examples of emerging applications. J Proteome Res. 2012 Nov 2;11(11):5124-34.. Epub 2012 May 25. PubMed PMID: 22607352.

Thelin, M.A., Svensson, K.J., Shi, X., Bagher, M., Axelsson, J., Isinger-Ekstrand, A., van Kuppevelt, T.H., Johansson, J., Nilbert, M., Zaia, J., Belting, M., Maccarana, M., Malmström, A. Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. Cancer Res. 2012 Apr 15;72(8):1943-52. Epub 2012 Feb 20. PMCID: PMC3328612.


2011

Svensson, K.J., Christianson, H.C., Kucharzewska, P., Fagerström, V., Lundstedt, L., Borgquist, S., Jirström, K., Belting, M. Chondroitin sulfate expression predicts poor outcome in breast cancer. Int J Oncol. 2011 Dec;39(6):1421-8. Epub 2011 Aug 17. PubMed PMID: 21850370.

Svensson, K.J., Kucharzewska, P., Christianson, H.C., Sköld, S., Löfstedt, T., Johansson, M.C., Mörgelin, M., Bengzon, J., Ruf ,W., Belting, M. Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13147-52. PMCID: PMC3156184.

Welch, J., Svensson, K., Kucharzewska, P., Belting, M. Heparan sulfate proteoglycan-mediated polyamine uptake. Methods Mol Biol. 2011;720:327-38. PubMed PMID: 21318883.


2010

Kucharzewska, P., Welch, J.E., Svensson, K.J., Belting, M. Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells. Exp Cell Res. 2010 Oct 1;316(16):2683-91. PubMed PMID: 20594968.

Wittrup, A., Zhang, S.H., Svensson, K.J., Kucharzewska, P., Johansson, M.C., Mörgelin, M., Belting, M. Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13342-7. PMCID: PMC2922147.


2009

Kucharzewska, P., Welch, J.E., Svensson, K.J., Belting, M. The polyamines regulate endothelial cell survival during hypoxic stress through PI3K/AKT and MCL-1. Biochem Biophys Res Commun. 2009 Mar 6;380(2):413-8. PubMed PMID: 19250631.


2008

Svensson, K.J., Welch, J.E., Kucharzewska, P., Bengtson, P., Bjurberg, M., Påhlman, S., Ten Dam, G.B., Persson, L., Belting, M. Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase. Cancer Res. 2008 Nov 15;68(22):9291-301. PubMed PMID: 19010902.

Welch, J.E., Bengtson, P., Svensson, K., Wittrup, A., Jenniskens, G.J., Ten Dam, G.B., Van Kuppevelt, T.H., Belting, M. Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation.  Int J Oncol. 2008 Apr;32(4):749-56. PubMed PMID: 18360702.


2007

Mani, K., Sandgren, S., Lilja, J., Cheng, F., Svensson, K., Persson, L., Belting, M. HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells. Mol Cancer Ther. 2007 Feb;6(2):782-8. PubMed PMID: 17308074.

Gardner, R.A., Belting, M., Svensson, K., Phanstiel, O 4th. Synthesis and transfection efficiencies of new lipophilic polyamines. J Med Chem. 2007 Jan 25;50(2):308-18. PubMed PMID: 17228872.