Mitochondrial uncoupler and retinoic acid synergistically induce differentiation and inhibit proliferation in neuroblastoma

Jiang H, Tiche SJ, He CJ, Jedoui M, Forgo B, Zhao M, He B, Li Y, Li AM, Truong AT, Ho J, Simmermaker C, Yang Y, Zhou MN, Hu Z, Cuthbertson DJ, Svensson KJ, Hazard FK, Shimada H, Chiu B, Ye J.

bioRxiv [Preprint]. 2024 Jan 25:2024.01.22.576741. doi: 10.1101/2024.01.22.576741. PMID: 38328117; PMCID: PMC10849550.

A class of secreted mammalian peptides with potential to expand cell-cell communication

Wiggenhorn, A.L., Abuzaid, H.Z., Coassolo, L., Li, L.L., Tanzo, J.T., Wei, W., Lyo, X., Svensson, K.J., Long, J.Z.

Nat Commun. 2023 Dec 8;14(1):8125. doi: 10.1038/s41467-023-43857-0. PMID: 38065934; PMCID: PMC10709327.

Size matters: the biochemical logic of ligand type in endocrine crosstalk.

Lone J.B., Long J.Z., Svensson, K.J.

Life Metabolism, 2023; load048, https://doi.org/10.1093/lifemeta/load048

Roles of Activin A and Gpnmb in metabolic dysfunction-associated steatotic liver disease (MASLD)

Liu. H., Yerevanian, A., Westerhoff, M., Hastings, M.H., Guerra, J.R.B., Zhao, M., Svensson, K.J., Cai, B., Soukas, A.A., Rosenzweig, A. Roles of Activin A and Gpnmb in metabolic dysfunction-associated steatotic liver disease (MASLD).

Diabetes. 2023 Nov 7:db230357. doi: 10.2337/db23-0357. PMID: 37934943.

Hallmarks of the metabolic secretome

Reghupaty. S.C., Dall, N.R., Svensson, K.J.

Trends Endocrinol Metab. 2023 Oct 14:S1043-2760(23)00195-9. doi: 10.1016/j.tem.2023.09.006. Epub ahead of print. PMID: 37845120.

Organism-wide, cell-type-specific secretome mapping of exercise training in mice

Wei, W., Riley, N.M., Lyu, X., Shen, X., Guo, J., Raun, S.H., Zhao, M., Moya-Garzon, M.D., Basu, H., Sheng-Hwa Tung, A., Li, V.L., Huang, W., Wiggenhorn, A.L., Svensson, K.J., Snyder, M.P., Bertozzi, C.R., Long. J.Z.

Cell Metab. 2023 Apr 28:S1550-4131(23)00138-9. doi: 10.1016/j.cmet.2023.04.011. PMID: 37141889.

Rapid and accurate deorphanization of ligand-receptor pairs using AlphaFold

Danneskiold-Samsoee, N.B., Kavi, D., Jude, K.M., Nissen, S.B., Wat, L.W., Coassolo, L., Zhao, M., Santana-Oikawa, G.A., Broido, B.B., K.C. Garcia, Svensson, K.J.

bioRxiv 2023 03.16.531341

Protocol for in vivo measurement of basal and insulin-stimulated glucose uptake in mouse tissues

Zhao M., Wat, L.W., Svensson, K.J.

STAR Protocols, 2023, Volume 4, Issue 2, 102179, ISSN 2666-1667.

Mapping transcriptional heterogeneity and metabolic networks in fatty livers at single-cell resolution

Coassolo, L. , Liu, T., Jung, Y., Taylor, N.P. , Zhao, Z., Charville, G.W., Nissen, S.B., Yki-Jarvinen, H., Altman, R., Svensson, K.J.

iScience, 2022, 105802.

G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

Bielczyk-Maczynska, E., Zhao, M., P-J H. Zushin, Schnurr T.M., Kim, H-J., Li, J., Nallagatla, P., Sangwung, P., Park, C., Cornn C., Stahl A., Svensson K.J., Knowles, J.W.

Nat Commun 13, 7408 (2022).

Phosphoproteomic mapping reveals distinct signaling actions and activation of protein synthesis by Isthmin-1

Zhao M., Banhos Danneskiold-Samsøe, N., Ulicna, L., Nguyen, Q., Voilquin, L., Lee, D.E., White, J.P., Jiang, Z., Cuthbert, N., Paramasivam, S., Bielczyk-Maczynska, E., Van Rechem, C., Svensson, K.J.

eLife 11:e80014 https://doi.org/10.7554/eLife.80014

New players of the adipose secretome: Therapeutic opportunities and challenges (Review)

Coassolo L., Dannieskiold-Samsøe, N. B., Zhao, M., Allen, H., Svensson, K.J.

Curr. Opin. Pharmacol. 67, 102302 (2022). https://doi.org/10.1016/j.coph.2022.102302

Isthmin-1 As A Modulator Of Metabolic Health (Conference abstract)

Zhao M., Danneskiold-Samsøe N.B., Voilquin, L., Jiang, Z., Svensson, K.J. LBMON185. Isthmin-1 As A Modulator Of Metabolic Health

Journal of the Endocrine Society, Volume 6, Issue Supplement_1, November-December 2022, Page A587.

CROP-Seq: a single-cell CRISPRi platform for characterizing candidate genes relevant to metabolic disorders in human adipocytes

Bielczyk-Maczynska, E, Sharma, D., Blencowe, M., Gustafsson, P.S., Gloudemans, M., Chong, P., Yang, X., Wabitsch, M., Svensson, K.J., Quertermous, T., Knowles, J.W, Li, J..

bioRxiv 2022.06.27.497796 (2022) https://doi.org/10.1101/2022.06.27.497796

Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

Jiang Z., Zhao, M., Voilquin, L., Jung, Y., Aikio, M.A., Sahai, T., Dou, F.Y., Roche, A.M., Carcamo-Orive, I., Knowles, J.W., Wabitsch, M., Appel, A.E., Maikawa, C.L., Camporez, J.P., Shulman, G.I., Tsai, L., Rosen, E.D., Gardner, C.D., Spiegelman, B.M., Svensson, K.J.

Cell Metabolism. 2021, https://doi.org/10.1016/j.cmet.2021.07.010.

·      Nature Reviews Endocrinology (2021). News & Views - Heeren, J., Scheja, L. Isthmin 1 — a novel insulin-like adipokine. 

·      BioCentury (Aug 27, 2021). ISM1 as a therapy for diabetes, fatty liver disease.

·      Stanford Cardiovascular Institute (Sept 29, 2021). Steps towards simultaneously treating diabetes and fatty liver disease.

·     J Diabetes Investig. (2022) Shimizu T, Takahashi Y, Fujita H, Waki H. Pick the best of both glucose and lipid metabolism.

Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury

O’Brien, C.G., Ozen, M.O., Ikeda, G., Vaskova, E., Jung, J., Bayardo, N., Santoso, M.R., Shi, L., Wahlquist, C. , Jiang, Z., Jung, Y., Zeng, Y., Egan, E., Sinclair, R., Gee, A., Witteles, R., Mercola, M., Svensson, K.J., Demirci, U., Yang, P.C. Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury

JACC: CardioOncology. (2021) 0(0). doi: 10.1016/j.jaccao.2021.05.006.

Isolation, culture, and functional analysis of hepatocytes from mice with fatty liver disease

Jung, Y., Zhao, M., Svensson, K.J.

STAR Protocols. Dec 18. 2020. DOI: 10.1016/j.xpro.2020.100222

A CRISPR-based genome-wide screen for adipogenesis reveals new insights into mitotic expansion and lipogenesis

Hilgendorf, K. I. Johnson, C.T.,  Han, K.,  Rabiee, A.,  Demeter J.,  Cheng, R.,  Zhu, Y.,  Jiang, Z., Svensson, K.J.,  Bassik, M.C.,  Jackson P.K.

BioRxiv, 2020. https://doi.org/10.1101/2020.07.13.201038

Regulation of energy metabolism by receptor tyrosine kinase ligands

Zhao, M., Jung Y., Jiang, Z., Svensson, K.J.

Frontiers in Physiology, 21 April 2020.

Ladbury J: Faculty Opinions Recommendation, 28 May 2020; 10.3410/f.737907472.793574673

Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception

Long, J.Z., Roche, A.M., Berdan, C.A., Louie, S.M., Roberts, A.J., Svensson, K.J., Dou, F.Y., Bateman, L.A., Mina, A.I., Deng, Z., Jedrychowski, M.P., Lin, H., Kamenecka, T.M., Asara, J.M., Griffin, P.R., Banks, A.S., Nomura, D.K., Spiegelman, B.M.

PNAS. 2018 Jul 2. PMID: 29967167.

Discovery of Hydrolysis-resistant Isoindoline N-Acyl Amino Acid Analogs that Stimulate Mitochondrial Respiration

Lin, H., Long, J.Z., Roche, A.M., Svensson, K.J., Dou, F.Y., Chang, M.R., Strutzenberg, T., Ruiz, C., Cameron, M.D., Novick, S.J., Berdan, C.M., Louie, S., Nomura, D.K., Spiegelman, B.M., Griffin, P.R., Kamenecka, T.M.

J Med Chem. 2018,12;61(7):3224-3230 PMID: 29533650.

Prior to Stanford

PM20D1 secretion by thermogenic adipocytes regulates lipidated amino acid uncouplers of mitochondrial respiration

Long, J.Z., Svensson, K.J., Bateman, L.A., Lin, H., Kamenecka, T., Lokurkar, I.A., Lou, J., Rao, R.R., Chang, M.R., Jedrychowski, M., Paulo, J.A., Gygi, S.P., Griffin, P.R., Nomura, D.K., Spiegelman, B.M.

Cell. 2016 166(2):424-35. PMCID: PMC4947008.

Hypoxia and acidosis induced extracellular lipid uptake promotes metastasis through proteoglycan dependent endocytosis

Menard, J.A., Christianson, H.C., Kucharzewska, P., Bourseau-Guilmain, E., Svensson, K.J., Lindqvist, E., Chandran, V.I., Kjellén, L., Bengzon, J., Johansson, M.C., Belting, M.

Cancer Research. 2016 May 19. pii: canres.2831.2015. PubMed PMID: 27199348.

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

Svensson, K.J., Long, J.Z., Jedrychowski, M.P., Cohen, P., Lo, J.C., Serag, S., Kir, S., Shinoda, K., Tartaglia, J.A., Rao, R.R., Chédotal, A., Kajimura, S., Gygi, S.P., Spiegelman, B.M. 

Cell Metabolism. 2016 23(3):454-66 PubMed PMCID: PMC4785066.  

Exosome and microvesicle mediated phene transfer in mammalian cells

Christianson, H.C., Svensson, K.J., Belting, M. 

Semin Cancer Biol. 2014 Oct;28:31-8. PMID: 24769057.

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

Rao, R.R., Long, J.Z., White, J.P., Svensson, K.J., Lou, J., Lokurkar, I., Jedrychowski, M.P., Ruas, J.L., Wrann, C.D., Lo, J.C., Camera, D.M., Lachey, J., Gygi, S., Seehra, J., Hawley, J.A., Spiegelman, B.M.  

Cell. 2014 Jun 5;157(6):1279-91. PMCID: PMC4131287.

 A smooth muscle-like origin for beige adipocytes

Long, J.Z., Svensson, K.J., Tsai, L., Zeng, X., Roh, H.C., Kong, X., Rao, R.R., Lou, J., Lokurkar, I., Baur, W., Castellot, J.J. Jr, Rosen, E.D., Spiegelman, B.M.

Cell Metabolism. 2014 May 6;19(5):810-20. PMCID: PMC4052772.

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch

Cohen, P., Levy, J.D., Zhang, Y., Frontini, A., Kolodin, D.P., Svensson, K.J., Lo, J.C., Zeng, X., Ye, L., Khandekar, M.J., Wu, J., Gunawardana, S.C., Banks, A.S., Camporez, J.P., Jurczak, M.J., Kajimura, S., Piston, D.W., Mathis, D., Cinti, S., Shulman, G.I., Seale, P., Spiegelman, B.M.  

Cell. 2014 Jan 16;156(1-2):304-16. PMCID: PMC3922400.

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

Christianson, H.C., Svensson, K.J., van Kuppevelt, T.H., Li, J.P., Belting, M. 

PNAS. 2013 Oct 22;110(43):17380-5. PMCID: PMC3808637.

Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1

Svensson, K.J.*, Christianson, H.C., Wittrup, A., Bourseau-Guilmain, E., Lindqvist, E., Svensson, L.M., Mörgelin, M., Belting, M.  

J Biol Chem. 2013 Jun 14;288(24):17713-24. Epub 2013 May 7. PMCID: PMC3682571.  *Corresponding author.

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Kucharzewska, P., Christianson, H.C., Welch, J.E., Svensson, K.J., Fredlund, E., Ringnér, M., Morgelin, M., Bourseau-Guilmain, E., Bengzon, J., Belting, M. 

PNAS. 2013 Apr 30;110(18):7312-7. PMCID: PMC3645587.

Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment

Svensson, K.J., Belting, M. 

Biochem Soc Trans. 2013 Feb 1;41(1):273-6. PubMed PMID: 23356296.

Standardization and utilization of biobank resources in clinical protein science with examples of emerging applications

Marko-Varga, G., Végvári, Á., Welinder, C., Lindberg, H., Rezeli, M., Edula, G., Svensson, K.J., Belting, M., Laurell, T., Fehniger, T.E.  

J Proteome Res. 2012 Nov 2;11(11):5124-34.. Epub 2012 May 25. PubMed PMID: 22607352.

Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma

Thelin, M.A., Svensson, K.J., Shi, X., Bagher, M., Axelsson, J., Isinger-Ekstrand, A., van Kuppevelt, T.H., Johansson, J., Nilbert, M., Zaia, J., Belting, M., Maccarana, M., Malmström, A.

 Cancer Research. 2012 Apr 15;72(8):1943-52. Epub 2012 Feb 20. PMCID: PMC3328612.

Chondroitin sulfate expression predicts poor outcome in breast cancer

Svensson, K.J., Christianson, H.C., Kucharzewska, P., Fagerström, V., Lundstedt, L., Borgquist, S., Jirström, K., Belting, M.  

Int J Oncol. 2011 Dec;39(6):1421-8. Epub 2011 Aug 17. PubMed PMID: 21850370.

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells

Svensson, K.J., Kucharzewska, P., Christianson, H.C., Sköld, S., Löfstedt, T., Johansson, M.C., Mörgelin, M., Bengzon, J., Ruf ,W., Belting, M.  

PNAS. 2011 Aug 9;108(32):13147-52. PMCID: PMC3156184.

Heparan sulfate proteoglycan-mediated polyamine uptake

Welch, J., Svensson, K., Kucharzewska, P., Belting, M.  

Methods Mol Biol. 2011;720:327-38. PubMed PMID: 21318883.

Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells

Kucharzewska, P., Welch, J.E., Svensson, K.J., Belting, M.  

Exp Cell Res. 2010 Oct 1;316(16):2683-91. PubMed PMID: 20594968.

Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery

Wittrup, A., Zhang, S.H., Svensson, K.J., Kucharzewska, P., Johansson, M.C., Mörgelin, M., Belting, M.  

PNAS. 2010 Jul 27;107(30):13342-7. PMCID: PMC2922147.

The polyamines regulate endothelial cell survival during hypoxic stress through PI3K/AKT and MCL-1

Kucharzewska, P., Welch, J.E., Svensson, K.J., Belting, M.  

Biochem Biophys Res Commun. 2009 Mar 6;380(2):413-8. PubMed PMID: 19250631.

Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase

Svensson, K.J., Welch, J.E., Kucharzewska, P., Bengtson, P., Bjurberg, M., Påhlman, S., Ten Dam, G.B., Persson, L., Belting, M. 

Cancer Research. 2008 Nov 15;68(22):9291-301. PubMed PMID: 19010902.

Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation

Welch, J.E., Bengtson, P., Svensson, K., Wittrup, A., Jenniskens, G.J., Ten Dam, G.B., Van Kuppevelt, T.H., Belting, M.  

Int J Oncol. 2008 Apr;32(4):749-56. PubMed PMID: 18360702.

HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells

Mani, K., Sandgren, S., Lilja, J., Cheng, F., Svensson, K., Persson, L., Belting, M.  

Mol Cancer Ther. 2007 Feb;6(2):782-8. PubMed PMID: 17308074.

Synthesis and transfection efficiencies of new lipophilic polyamines

Gardner, R.A., Belting, M., Svensson, K., Phanstiel, O 4th.  

J Med Chem. 2007 Jan 25;50(2):308-18. PubMed PMID: 17228872.