Phosphoproteomic mapping reveals distinct signaling actions and activation of protein synthesis and muscle hypertrophy by Isthmin-1
Zhao M., Banhos Dannieskiold-Samsøe, N., Ulicna, L., Nguyen, Q., Voilquin, L., Lee, D.E., White, J.P., Jiang, Z., Cuthbert, N., Paramasivam, S., Bielczyk-Maczynska, E., Van Rechem, C., Svensson, K.J.
bioRxiv, 2022.05.19.492758 (2022). https://www.biorxiv.org/content/10.1101/2022.05.19.492758v2
CROP-Seq: a single-cell CRISPRi platform for characterizing candidate genes relevant to metabolic disorders in human adipocytes
Bielczyk-Maczynska, E, Sharma, D., Blencowe, M., Gustafsson, P.S., Gloudemans, M., Chong, P., Yang, X., Wabitsch, M., Svensson, K.J., Quertermous, T., Knowles, J.W, Li, J..
bioRxiv 2022.06.27.497796 (2022) https://doi.org/10.1101/2022.06.27.497796
G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis
Bielczyk-Maczynska, E., Zhao, M., P-J H. Zushin, Schnurr T.M., Kim, H-J., Li, J., Nallagatla, P., Sangwung, P., Park, C., Cornn C., Stahl A., Svensson K.J., Knowles, J.W.
bioRxiv 2022.05.25.493489 (2022) https://doi.org/10.1101/2022.05.25.493489
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
Jiang Z., Zhao, M., Voilquin, L., Jung, Y., Aikio, M.A., Sahai, T., Dou, F.Y., Roche, A.M., Carcamo-Orive, I., Knowles, J.W., Wabitsch, M., Appel, A.E., Maikawa, C.L., Camporez, J.P., Shulman, G.I., Tsai, L., Rosen, E.D., Gardner, C.D., Spiegelman, B.M., Svensson, K.J.
Cell Metabolism. 2021, https://doi.org/10.1016/j.cmet.2021.07.010.
· Nature Reviews Endocrinology (2021). News & Views - Heeren, J., Scheja, L. Isthmin 1 — a novel insulin-like adipokine.
· BioCentury (Aug 27, 2021). ISM1 as a therapy for diabetes, fatty liver disease.
· Stanford Cardiovascular Institute (Sept 29, 2021). Steps towards simultaneously treating diabetes and fatty liver disease.
· J Diabetes Investig. (2022) Shimizu T, Takahashi Y, Fujita H, Waki H. Pick the best of both glucose and lipid metabolism.
Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury
O’Brien, C.G., Ozen, M.O., Ikeda, G., Vaskova, E., Jung, J., Bayardo, N., Santoso, M.R., Shi, L., Wahlquist, C. , Jiang, Z., Jung, Y., Zeng, Y., Egan, E., Sinclair, R., Gee, A., Witteles, R., Mercola, M., Svensson, K.J., Demirci, U., Yang, P.C. Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury
JACC: CardioOncology. (2021) 0(0). doi: 10.1016/j.jaccao.2021.05.006.
Isolation, culture, and functional analysis of hepatocytes from mice with fatty liver disease
Jung, Y., Zhao, M., Svensson, K.J.
STAR Protocols. Dec 18. 2020. DOI: 10.1016/j.xpro.2020.100222
A CRISPR-based genome-wide screen for adipogenesis reveals new insights into mitotic expansion and lipogenesis
Hilgendorf, K. I. Johnson, C.T., Han, K., Rabiee, A., Demeter J., Cheng, R., Zhu, Y., Jiang, Z., Svensson, K.J., Bassik, M.C., Jackson P.K.
BioRxiv, 2020. https://doi.org/10.1101/2020.07.13.201038
Regulation of energy metabolism by receptor tyrosine kinase ligands
Zhao, M., Jung Y., Jiang, Z., Svensson, K.J.
Frontiers in Physiology, 21 April 2020.
Ladbury J: Faculty Opinions Recommendation, 28 May 2020; 10.3410/f.737907472.793574673
Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception
Long, J.Z., Roche, A.M., Berdan, C.A., Louie, S.M., Roberts, A.J., Svensson, K.J., Dou, F.Y., Bateman, L.A., Mina, A.I., Deng, Z., Jedrychowski, M.P., Lin, H., Kamenecka, T.M., Asara, J.M., Griffin, P.R., Banks, A.S., Nomura, D.K., Spiegelman, B.M.
PNAS. 2018 Jul 2. PMID: 29967167.
Discovery of Hydrolysis-resistant Isoindoline N-Acyl Amino Acid Analogs that Stimulate Mitochondrial Respiration
Lin, H., Long, J.Z., Roche, A.M., Svensson, K.J., Dou, F.Y., Chang, M.R., Strutzenberg, T., Ruiz, C., Cameron, M.D., Novick, S.J., Berdan, C.M., Louie, S., Nomura, D.K., Spiegelman, B.M., Griffin, P.R., Kamenecka, T.M.
J Med Chem. 2018,12;61(7):3224-3230 PMID: 29533650.
Prior to Stanford
PM20D1 secretion by thermogenic adipocytes regulates lipidated amino acid uncouplers of mitochondrial respiration
Long, J.Z., Svensson, K.J., Bateman, L.A., Lin, H., Kamenecka, T., Lokurkar, I.A., Lou, J., Rao, R.R., Chang, M.R., Jedrychowski, M., Paulo, J.A., Gygi, S.P., Griffin, P.R., Nomura, D.K., Spiegelman, B.M.
Cell. 2016 166(2):424-35. PMCID: PMC4947008.
Hypoxia and acidosis induced extracellular lipid uptake promotes metastasis through proteoglycan dependent endocytosis
Menard, J.A., Christianson, H.C., Kucharzewska, P., Bourseau-Guilmain, E., Svensson, K.J., Lindqvist, E., Chandran, V.I., Kjellén, L., Bengzon, J., Johansson, M.C., Belting, M.
Cancer Research. 2016 May 19. pii: canres.2831.2015. PubMed PMID: 27199348.
A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function
Svensson, K.J., Long, J.Z., Jedrychowski, M.P., Cohen, P., Lo, J.C., Serag, S., Kir, S., Shinoda, K., Tartaglia, J.A., Rao, R.R., Chédotal, A., Kajimura, S., Gygi, S.P., Spiegelman, B.M.
Cell Metabolism. 2016 23(3):454-66 PubMed PMCID: PMC4785066.
Exosome and microvesicle mediated phene transfer in mammalian cells
Christianson, H.C., Svensson, K.J., Belting, M.
Semin Cancer Biol. 2014 Oct;28:31-8. PMID: 24769057.
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
Rao, R.R., Long, J.Z., White, J.P., Svensson, K.J., Lou, J., Lokurkar, I., Jedrychowski, M.P., Ruas, J.L., Wrann, C.D., Lo, J.C., Camera, D.M., Lachey, J., Gygi, S., Seehra, J., Hawley, J.A., Spiegelman, B.M.
Cell. 2014 Jun 5;157(6):1279-91. PMCID: PMC4131287.
A smooth muscle-like origin for beige adipocytes
Long, J.Z., Svensson, K.J., Tsai, L., Zeng, X., Roh, H.C., Kong, X., Rao, R.R., Lou, J., Lokurkar, I., Baur, W., Castellot, J.J. Jr, Rosen, E.D., Spiegelman, B.M.
Cell Metabolism. 2014 May 6;19(5):810-20. PMCID: PMC4052772.
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
Cohen, P., Levy, J.D., Zhang, Y., Frontini, A., Kolodin, D.P., Svensson, K.J., Lo, J.C., Zeng, X., Ye, L., Khandekar, M.J., Wu, J., Gunawardana, S.C., Banks, A.S., Camporez, J.P., Jurczak, M.J., Kajimura, S., Piston, D.W., Mathis, D., Cinti, S., Shulman, G.I., Seale, P., Spiegelman, B.M.
Cell. 2014 Jan 16;156(1-2):304-16. PMCID: PMC3922400.
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
Christianson, H.C., Svensson, K.J., van Kuppevelt, T.H., Li, J.P., Belting, M.
PNAS. 2013 Oct 22;110(43):17380-5. PMCID: PMC3808637.
Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1
Svensson, K.J.*, Christianson, H.C., Wittrup, A., Bourseau-Guilmain, E., Lindqvist, E., Svensson, L.M., Mörgelin, M., Belting, M.
J Biol Chem. 2013 Jun 14;288(24):17713-24. Epub 2013 May 7. PMCID: PMC3682571. *Corresponding author.
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
Kucharzewska, P., Christianson, H.C., Welch, J.E., Svensson, K.J., Fredlund, E., Ringnér, M., Morgelin, M., Bourseau-Guilmain, E., Bengzon, J., Belting, M.
PNAS. 2013 Apr 30;110(18):7312-7. PMCID: PMC3645587.
Role of extracellular membrane vesicles in intercellular communication of the tumour microenvironment
Svensson, K.J., Belting, M.
Biochem Soc Trans. 2013 Feb 1;41(1):273-6. PubMed PMID: 23356296.
Standardization and utilization of biobank resources in clinical protein science with examples of emerging applications
Marko-Varga, G., Végvári, Á., Welinder, C., Lindberg, H., Rezeli, M., Edula, G., Svensson, K.J., Belting, M., Laurell, T., Fehniger, T.E.
J Proteome Res. 2012 Nov 2;11(11):5124-34.. Epub 2012 May 25. PubMed PMID: 22607352.
Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma
Thelin, M.A., Svensson, K.J., Shi, X., Bagher, M., Axelsson, J., Isinger-Ekstrand, A., van Kuppevelt, T.H., Johansson, J., Nilbert, M., Zaia, J., Belting, M., Maccarana, M., Malmström, A.
Cancer Research. 2012 Apr 15;72(8):1943-52. Epub 2012 Feb 20. PMCID: PMC3328612.
Chondroitin sulfate expression predicts poor outcome in breast cancer
Svensson, K.J., Christianson, H.C., Kucharzewska, P., Fagerström, V., Lundstedt, L., Borgquist, S., Jirström, K., Belting, M.
Int J Oncol. 2011 Dec;39(6):1421-8. Epub 2011 Aug 17. PubMed PMID: 21850370.
Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells
Svensson, K.J., Kucharzewska, P., Christianson, H.C., Sköld, S., Löfstedt, T., Johansson, M.C., Mörgelin, M., Bengzon, J., Ruf ,W., Belting, M.
PNAS. 2011 Aug 9;108(32):13147-52. PMCID: PMC3156184.
Heparan sulfate proteoglycan-mediated polyamine uptake
Welch, J., Svensson, K., Kucharzewska, P., Belting, M.
Methods Mol Biol. 2011;720:327-38. PubMed PMID: 21318883.
Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells
Kucharzewska, P., Welch, J.E., Svensson, K.J., Belting, M.
Exp Cell Res. 2010 Oct 1;316(16):2683-91. PubMed PMID: 20594968.
Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery
Wittrup, A., Zhang, S.H., Svensson, K.J., Kucharzewska, P., Johansson, M.C., Mörgelin, M., Belting, M.
PNAS. 2010 Jul 27;107(30):13342-7. PMCID: PMC2922147.
The polyamines regulate endothelial cell survival during hypoxic stress through PI3K/AKT and MCL-1
Kucharzewska, P., Welch, J.E., Svensson, K.J., Belting, M.
Biochem Biophys Res Commun. 2009 Mar 6;380(2):413-8. PubMed PMID: 19250631.
Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase
Svensson, K.J., Welch, J.E., Kucharzewska, P., Bengtson, P., Bjurberg, M., Påhlman, S., Ten Dam, G.B., Persson, L., Belting, M.
Cancer Research. 2008 Nov 15;68(22):9291-301. PubMed PMID: 19010902.
Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation
Welch, J.E., Bengtson, P., Svensson, K., Wittrup, A., Jenniskens, G.J., Ten Dam, G.B., Van Kuppevelt, T.H., Belting, M.
Int J Oncol. 2008 Apr;32(4):749-56. PubMed PMID: 18360702.
HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells
Mani, K., Sandgren, S., Lilja, J., Cheng, F., Svensson, K., Persson, L., Belting, M.
Mol Cancer Ther. 2007 Feb;6(2):782-8. PubMed PMID: 17308074.
Synthesis and transfection efficiencies of new lipophilic polyamines
Gardner, R.A., Belting, M., Svensson, K., Phanstiel, O 4th.
J Med Chem. 2007 Jan 25;50(2):308-18. PubMed PMID: 17228872.