Identifying new hormones and secreted proteins with unknown function
We believe that the majority of blood proteins are uncharacterized, and that we with new proteomic and genomic techniques we can discover and uncover new functions of previously uncharacterized hormones. One of our goals are to identify new, unknown secreted factors with a putative function in metabolic disease.
Development of new protein therapeutics to target metabolic disease
New putative translational protein or peptide candidates are produced recombinantly in mammalian systems and tested for their bioactive function by using in vitro and in vivo models.
Generating genetically engineered mice and gene therapy models to study the physiologic activity of hormones in mice
By generating genetically engineered mice and adeno-associated virus (AAV) gene therapy models for loss-and gain of function of secreted factors, we are studying new factors that are involved in energy metabolism.
Assay development for identifying biomarkers of metabolic disease
Using proteomic and genomic techniques in combination with biochemical purification of nucleic acids or proteins from complex biological materials such as plasma or tissues, the goal is to identify markers of early metabolic disease.
We are using the qNano Gold instrument for the measurement of nanoparticles such as extracellular vesicles, exosomes or microvesicles in biological materials. This system uses tunable resistive pulse sensing to determine the particle size, distribution, concentration and charge.